Structural rankings

Results 1 to 10

Restricting to entries for author: PAVLETICH, N.P.

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Molecule	Release date	Citations	Downloads	Final score	Order crystal
TUMOR SUPPRESSOR P53 COMPLEXED WITH DNA	Molecular functions: (select from list to view only structures with selected function) Activation of caspase activity by cytochrome cApoptosisATP bindingB cell lineage commitmentBase-excision repairCell agingCell cycleCell cycle arrestCell differentiationCell proliferationCellular response to glucose starvationCellular response to UVCentral nervous system developmentChaperone bindingChromatin bindingChromosome organizationCopper ion bindingCytoplasmCytosolDNA bindingDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resultiDNA strand annealing activityDouble-strand break repairEmbryonic development ending in birth or egg hatchingEndoplasmic reticulumEnzyme bindingER overload responseG1 DNA damage checkpointGastrulationIn utero embryonic developmentInduction of apoptosisInduction of apoptosis by intracellular signalsInsoluble fractionInterspecies interaction between organismsMetal ion bindingMitochondrionMulticellular organismal developmentNegative regulation of apoptosisNegative regulation of cell cycleNegative regulation of cell growthNegative regulation of DNA replicationNegative regulation of fibroblast proliferationNegative regulation of helicase activityNegative regulation of neuroblast proliferationNegative regulation of transcription from RNA polymerase II promoterNuclear matrixNucleolusNucleoplasmNucleotide-excision repairNucleusPML bodyPositive regulation of apoptosisPositive regulation of neuron apoptosisPositive regulation of specific transcription from RNA polymerase II pPositive regulation of transcription from RNA polymerase II promoterProtein bindingProtein complex assemblyProtein heterodimerization activityProtein import into nucleus, translocationProtein localizationProtein N-terminus bindingProtein tetramerizationRegulation of apoptosisRegulation of intracellular pHRegulation of mitochondrial membrane permeabilityRegulation of transcriptionRegulation of transcription, DNA-dependentRelease of cytochrome c from mitochondriaReplication forkResponse to DNA damage stimulusResponse to drugResponse to gamma radiationResponse to salt stressResponse to tumor cellResponse to X-rayRNA-protein covalent cross-linkingT cell differentiation in the thymusT cell lineage commitmentT cell proliferation during immune responseTranscriptionTranscription factor activityZinc ion binding
	1995-07-11	440	21557	1275	Order structure laser-etched in crystal
ZINC FINGER-DNA RECOGNITION: CRYSTAL STRUCTURE OF A ZIF268-DNA COMPLEX AT 2.1 ANGSTROMS	Molecular functions: (select from list to view only structures with selected function) DNA bindingIntracellularLearning or memoryMetal ion bindingNegative regulation of transcription from RNA polymerase II promoterNucleic acid bindingNucleusPositive regulation of transcription from RNA polymerase II promoterRegulation of transcription, DNA-dependentResponse to protein stimulusT cell differentiationTranscriptionTranscription activator activityTranscription factor activityZinc ion binding
	1993-10-31	392	14918	746	Order structure laser-etched in crystal
CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX	Molecular functions: (select from list to view only structures with selected function) ATP bindingCell cycleCell divisionCyclin-dependent protein kinase activityCyclin-dependent protein kinase holoenzyme complexCytoplasmCytosolDNA replicationFemale pronucleusG2/M transition of mitotic cell cycleHistone kinase activityIdentical protein bindingKinase activityMale pronucleusMitosisMitotic cell cycle G2/M transition DNA damage checkpointNucleoplasmNucleotide bindingNucleusPositive regulation of cell proliferationPositive regulation of transcriptionProtein amino acid phosphorylationProtein bindingProtein kinase activityProtein serine/threonine kinase activityRegulation of DNA replicationTransferase activityTraversing start control point of mitotic cell cycle
	1997-01-27	312	16452	729	Order structure laser-etched in crystal
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex	Molecular functions: (select from list to view only structures with selected function) ApoptosisCell cycle arrestCell proliferationCullin-RING ubiquitin ligase complexCytoplasmCytosolDNA repairG1/S transition of mitotic cell cycleInduction of apoptosis by intracellular signalsMetal ion bindingModification-dependent protein catabolic processNEDD8 ligase activityNegative regulation of cell proliferationNegative regulation of survival gene product expressionNucleoplasmNucleusOrgan morphogenesisPositive regulation of ubiquitin-protein ligase activity during mitotiProtein bindingProtein neddylationRegulation of cell cycleResponse to DNA damage stimulusSCF ubiquitin ligase complexUbiquitin protein ligase bindingUbiquitin-dependent protein catabolic processZinc ion binding
	2002-05-08	229	13133	546	Order structure laser-etched in crystal
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex	Molecular functions: (select from list to view only structures with selected function) ApoptosisCell cycle arrestCell proliferationCullin-RING ubiquitin ligase complexCytoplasmCytosolDNA repairG1/S transition of mitotic cell cycleInduction of apoptosis by intracellular signalsMetal ion bindingModification-dependent protein catabolic processNEDD8 ligase activityNegative regulation of cell proliferationNucleoplasmNucleusOrgan morphogenesisPositive regulation of ubiquitin-protein ligase activity during mitotiProtein bindingProtein neddylationResponse to DNA damage stimulusSCF ubiquitin ligase complexUbiquitin protein ligase bindingUbiquitin-dependent protein catabolic processZinc ion binding
	2002-05-08	229	12010	499	Order structure laser-etched in crystal
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex	Molecular functions: (select from list to view only structures with selected function) Anaphase-promoting complexAnaphase-promoting complex-dependent proteasomal ubiquitin-dependent pCell cycleCell divisionCullin-RING ubiquitin ligase complexCyclin catabolic processCytoplasmMitosisMitotic metaphase/anaphase transitionMitotic sister chromatid segregationMitotic spindle elongationModification-dependent protein catabolic processNucleusProtein bindingProtein ubiquitinationUbiquitin protein ligase bindingUbiquitin-dependent protein catabolic processUbiquitin-protein ligase activity
	2002-05-08	229	10442	434	Order structure laser-etched in crystal
MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53	Molecular functions: (select from list to view only structures with selected function) Activation of caspase activity by cytochrome cApoptosisATP bindingB cell lineage commitmentBasal transcription repressor activityBase-excision repairCell agingCell cycleCell cycle arrestCell differentiationCell proliferationCellular response to glucose starvationCellular response to UVCentral nervous system developmentChaperone bindingChromatin bindingChromosome organizationCopper ion bindingCytoplasmCytosolDNA bindingDNA damage response, signal transduction by p53 class mediatorDNA damage response, signal transduction by p53 class mediator resultiDNA strand annealing activityDouble-strand break repairEmbryonic development ending in birth or egg hatchingEndoplasmic reticulumEnzyme bindingER overload responseG1 DNA damage checkpointGastrulationIdentical protein bindingIn utero embryonic developmentInduction of apoptosisInduction of apoptosis by intracellular signalsInsoluble fractionInterspecies interaction between organismsIntracellularLigase activityMetal ion bindingMitochondrionModification-dependent protein catabolic processMulticellular organismal developmentNegative regulation of apoptosisNegative regulation of cell cycleNegative regulation of cell growthNegative regulation of cell proliferationNegative regulation of DNA replicationNegative regulation of fibroblast proliferationNegative regulation of helicase activityNegative regulation of neuroblast proliferationNegative regulation of transcription from RNA polymerase II promoterNuclear matrixNucleolusNucleoplasmNucleotide-excision repairNucleusPML bodyPositive regulation of apoptosisPositive regulation of neuron apoptosisPositive regulation of specific transcription from RNA polymerase II pPositive regulation of transcription from RNA polymerase II promoterProtein bindingProtein complex assemblyProtein heterodimerization activityProtein import into nucleus, translocationProtein localizationProtein N-terminus bindingProtein tetramerizationProtein ubiquitinationRegulation of apoptosisRegulation of intracellular pHRegulation of mitochondrial membrane permeabilityRegulation of protein catabolic processRegulation of transcriptionRegulation of transcription, DNA-dependentRelease of cytochrome c from mitochondriaReplication forkResponse to DNA damage stimulusResponse to drugResponse to gamma radiationResponse to salt stressResponse to tumor cellResponse to X-rayRNA-protein covalent cross-linkingT cell differentiation in the thymusT cell lineage commitmentT cell proliferation during immune responseTranscriptionTranscription factor activityUbiquitin-protein ligase activityZinc ion binding
	1997-11-19	200	14514	425	Order structure laser-etched in crystal
P27(KIP1)/CYCLIN A/CDK2 COMPLEX	Molecular functions: (select from list to view only structures with selected function) ATP bindingAutophagic cell deathCell cycleCell cycle arrestCell divisionCyclin-dependent protein kinase activityCyclin-dependent protein kinase holoenzyme complexCyclin-dependent protein kinase inhibitor activityCytoplasmCytosolDNA replicationFemale pronucleusG1/S transition of mitotic cell cycleG2/M transition of mitotic cell cycleHistone kinase activityIdentical protein bindingInduction of apoptosisKinase activityMale pronucleusMitosisMitotic cell cycle G2/M transition DNA damage checkpointNegative regulation of cell growthNegative regulation of cell proliferationNegative regulation of phosphorylationNucleoplasmNucleotide bindingNucleusPositive regulation of cell proliferationPositive regulation of transcriptionProtein amino acid phosphorylationProtein bindingProtein kinase activityProtein kinase inhibitor activityProtein serine/threonine kinase activityRegulation of cyclin-dependent protein kinase activityRegulation of DNA replicationTransferase activityTransforming growth factor beta receptor, cytoplasmic mediator activitTraversing start control point of mitotic cell cycle
	1997-07-29	197	14320	408	Order structure laser-etched in crystal
STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES	Molecular functions: (select from list to view only structures with selected function) ATP bindingCalcium ion bindingCell surface receptor linked signal transductionCytoplasmCytosolEnzyme bindingEpidermal growth factor receptor signaling pathwayFlotillin complexLigase activityMetal ion bindingModification-dependent protein catabolic processNucleotide bindingNucleusPlasma membranePositive regulation of receptor-mediated endocytosisPost-translational protein modificationProtein bindingProtein modification processProtein ubiquitinationRegulation of protein metabolic processSH3 domain bindingSignal transducer activitySmall conjugating protein ligase activityTranscription factor activityUbiquitin ligase complexUbiquitin-dependent protein catabolic processUbiquitin-protein ligase activityZinc ion binding
	2000-08-30	174	13072	377	Order structure laser-etched in crystal
GELDANAMYCIN BOUND TO THE HSP90 GELDANAMYCIN-BINDING DOMAIN	Molecular functions: (select from list to view only structures with selected function) ATP bindingCellular chaperone-mediated protein complex assemblyCytoplasmCytosolMelanosomeMitochondrial outer membrane translocase complex assemblyMitochondrial transportNitric-oxide synthase regulator activityNucleotide bindingPositive regulation of nitric oxide biosynthetic processProtein bindingProtein foldingProtein homodimerization activityProtein refoldingResponse to stressResponse to unfolded proteinSignal transductionTPR domain bindingUnfolded protein binding
	1998-04-22	232	10659	368	Order structure laser-etched in crystal

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• Top Scientists

  1. MACKINNON, R.
  2. PAVLETICH, N.P.
  3. SIGLER, P.B.
  4. HARRISON, S.C.
  5. WILEY, D.C.
  6. JEFFREY, P.D.
  7. KURIYAN, J.
  8. CLEMONS JR., W.M.
  9. RAMAKRISHNAN, V.
  10. STEITZ, T.A.

• Top Functionality

  1. Photosystem II
  2. Thylakoid membrane
  3. Photosystem II reaction center
  4. Photosynthesis
  5. Estrogen response element binding
  6. Positive regulation of retinoic acid receptor signaling pathway
  7. Thylakoid
  8. Chromatin remodeling complex
  9. Estrogen receptor activity
  10. Estrogen receptor signaling pathway